Immunology Lecture Mini-Course, 2 of 14: Innate Immunity

www.einstein.yu.edu - Immunology Lecture 2 of 14 "Innate Immunity." Harris Goldstein, MD, director, Einstein-Montefiore Center for AIDS Research, professor of pediatrics and microbiology & immunology and the Charles Michael Chair in Autoimmune Diseases, delivers a mini-course that provides a comprehensive overview in basic immunology for graduate and medical students and for anyone interested in understanding how the immune system works. This mini-course was organized by the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) at the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa to provide Sub-Saharan students, research trainees and HIV and TB investigators with a comprehensive course in immunology. (January 2010). See related lecture slides at: streaming.einstein.yu.edu

Hamilton College Immunology Song/ Music Video High Quality Version: www.youtube.com [Chorus] If you and I want to bi~ind I need to recogni~ize Antigenic peptides Dont waste my time When will I find The one I can make mine [Verse 1] Dendritic Cell you know how we do Find you a protein and pursue Get it when its all alone Trap and localize in an endosome Then break, break, break it down Bind it with a class II MHC Express it on the surface all around So maybe I can find the right one for me All these complexes got me aggravated I really just want to be activated Yes I am a naïve CD4 Throw your hands up if you want some more Dont care bout the way you look Dont care how fat you are If you bind to my TCR I might give you a second look [Chorus] If you and I want to bi~ind I need to recogni~ize Antigenic peptides Dont waste my time When will I find The one I can make mine x 2 [Verse 2] Congrats you bind to my TCR But with only that you wont get far Bind to my CD4 co receptor If you cant then Ill see you later Dendritic Cell I need you to Bind your LFA-3 to my CD2 Wait where you going we aint done Your ICAM to my LFA-1 If you really want me to activate Bind your CD 80 to my CD28 Must have all the above to be my pick Dont be mad that Im too specific If you think that youre the one Come on over well have some fun If you turn out to be the right find Stimulate me with some cytokines [Chorus] If you and I want to bi~ind I need to recogni~ize Antigenic peptides Dont waste my time ...
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